1. - Madonna, Desperately Seeking Susan, 1985. Auditioned for the main Susan - director Susan Seidelman.
2. - Jennifer Jason Leigh, Miami Blues, 1990. The college kid-cum-hooker Susie Waggoner needed to be an actress. So Vega dropped out to make her third album, Days of Open Hand. Since then, Suzanne married twice, had a daughter - but never made a movie.