1. - Madonna, Desperately Seeking Susan, 1985. Auditioned  for the main  Susan - director Susan Seidelman.

2. - Jennifer Jason Leigh, Miami Blues, 1990. The college kid-cum-hooker Susie Waggoner needed to be an actress. So  Vega dropped out to make her third album, Days of Open Hand. Since then, Suzanne  married twice,  had a daughter - but never made a movie.